Moss Marc
Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S490-7. doi: 10.1086/432003.
The annual incidences of severe sepsis in several industrialized nations have recently been reported to be 50-100 cases per 100,000 persons. These numbers exceed the estimated rates for other diseases that hold a heightened public awareness, including breast cancer and acquired immune deficiency syndrome. There are also sex and race differences in the incidence of sepsis. Men are more likely than women to develop sepsis, with a mean annual relative risk of 1.28. Nonwhites are nearly twice as likely to develop sepsis as whites. These race and sex disparities in the incidence of sepsis are likely explained by differences in a variety of factors, including the presence of comorbid conditions. For example, chronic alcohol abuse is associated with a persistent fever, delayed resolution of symptoms, increased rates of bacteremia, increased use of intensive care, prolonged duration of hospital stay, and increased cost of hospitalization for infected patients.
最近有报道称，几个工业化国家中严重脓毒症的年发病率为每10万人中有50 - 100例。这些数字超过了其他引起公众高度关注的疾病的估计发病率，包括乳腺癌和获得性免疫缺陷综合征。脓毒症的发病率也存在性别和种族差异。男性比女性更易患脓毒症，年平均相对风险为1.28。非白人患脓毒症的可能性几乎是白人的两倍。脓毒症发病率的这些种族和性别差异可能是由多种因素的差异造成的，包括合并症的存在。例如，长期酗酒与持续发热、症状缓解延迟、菌血症发生率增加、重症监护使用增加、住院时间延长以及感染患者的住院费用增加有关。
