Radtke Freddy, Wilson Anne, MacDonald H Robson
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.
Bioessays. 2005 Nov;27(11):1117-28. doi: 10.1002/bies.20315.
The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of self-renewing systems. In this article, we review the role of Notch signaling in the hematopoietic system with particular emphasis on lymphocyte development and highlight the similarities in Notch function between Drosophila and mammalian differentiation processes. Recent studies indicating that aberrant NOTCH signaling is frequently linked to the induction of T leukemia in humans will also be discussed.
进化上保守的Notch信号通路在胎儿期和出生后调控广泛的细胞命运决定和分化过程。它参与胚胎器官发生以及自我更新系统稳态的维持。在本文中，我们综述Notch信号在造血系统中的作用，特别强调淋巴细胞发育，并突出果蝇和哺乳动物分化过程中Notch功能的相似性。还将讨论近期表明异常的NOTCH信号经常与人类T白血病诱导相关的研究。
