Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Kyoto, Japan.
Curr Opin Cell Biol. 2009 Dec;21(6):733-40. doi: 10.1016/j.ceb.2009.08.009. Epub 2009 Sep 23.
In the developing nervous system, differentiating neurons express Delta and activate Notch signaling in their neighboring cells. As a result of Notch activation, neuronal differentiation is inhibited in neighboring cells and they remain neural progenitor cells. Thus, differentiation of neurons and maintenance of neural progenitor cells are well balanced owing to Notch signaling. Recent studies revealed that Notch signaling is under the control of more complex and dynamic regulation than previously thought, such as cell cycle dependent activation and oscillating gene expression. We discuss here recent advances in understanding how Notch signaling is regulated in the developing nervous system and what outcome each type of regulation of Notch signaling leads to. We highlight the role of Notch signaling in proliferation and differentiation of neural progenitor cells.
在发育中的神经系统中，分化神经元在其相邻细胞中表达 Delta 并激活 Notch 信号通路。由于 Notch 的激活，相邻细胞中的神经元分化受到抑制，它们仍然是神经祖细胞。因此，由于 Notch 信号通路的作用，神经元的分化和神经祖细胞的维持达到了很好的平衡。最近的研究表明， Notch 信号通路的调控比以前认为的更为复杂和动态，例如细胞周期依赖性激活和基因表达的振荡。在这里，我们讨论了在发育中的神经系统中 Notch 信号通路调控的最新进展，以及 Notch 信号通路的每种调控方式会导致什么样的结果。我们强调了 Notch 信号通路在神经祖细胞增殖和分化中的作用。
