Schmahl Christian, Bremner J Douglas
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, D-68159 Mannheim, Germany.
J Psychiatr Res. 2006 Aug;40(5):419-27. doi: 10.1016/j.jpsychires.2005.08.011. Epub 2005 Oct 18.
Neuroimaging has become one of the most important methods in the investigation of the neurobiological underpinnings of borderline personality disorder. Structural and functional imaging studies have revealed dysfunction in different brain regions which seem to contribute to borderline symptomatology. This review presents relevant studies using different methodologies: volumetry of limbic and prefrontal regions, investigations of brain metabolism under resting conditions, studies of serotonergic neurotransmission, and challenge studies using emotional, stressful, and sensory stimuli. Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology.
神经影像学已成为研究边缘型人格障碍神经生物学基础的最重要方法之一。结构和功能成像研究揭示了不同脑区的功能障碍，这些脑区似乎与边缘型人格障碍的症状有关。本综述介绍了使用不同方法的相关研究：边缘系统和前额叶区域的体积测量、静息状态下脑代谢的研究、血清素能神经传递的研究，以及使用情绪、压力和感觉刺激的激发研究。前额叶边缘网络功能障碍被认为介导了大部分（如果不是全部）边缘型人格障碍的症状。
