Oono S, Tabei K, Tetsuka T, Asano Y
Department of Medicine, Jichi Medical School, Tochigi, Japan.
Eur J Clin Pharmacol. 1992;42(6):667-9. doi: 10.1007/BF00265934.
We have studied the pharmacokinetics of fluconazole in five patients on long-term haemodialysis. The single-pass extraction rate of the dialyzer was 59 (3.5)% (n = 4), and the serum concentration was reduced by haemodialysis for 3 or 4 h by 26 (3.2)% (n = 5) and 39 (2.2)% (n = 9) respectively. The estimated amount extracted by a dialysis of 4 h was 33 (3.2)% (n = 4) of the dose. During repeated administration the serum fluconazole concentration increased, reaching a plateau at about 4 times the peak concentration after the first dose. After discontinuing administration the serum fluconazole concentration fell by 25% in every 3 h dialysis session. We conclude that fluconazole should be given in the usual dose of 100 or 200 mg at the end of every haemodialysis session.
我们研究了氟康唑在5例长期接受血液透析患者体内的药代动力学。透析器的单次通过提取率为59（3.5）%（n = 4），血液透析3小时或4小时后血清浓度分别降低26（3.2）%（n = 5）和39（2.2）%（n = 9）。4小时透析估计提取的剂量为给药剂量的33（3.2）%（n = 4）。重复给药期间，血清氟康唑浓度升高，在首次给药后的峰值浓度约4倍时达到平台期。停药后，每次3小时的透析疗程中血清氟康唑浓度下降25%。我们得出结论，应在每次血液透析结束时按100或200mg的常规剂量给予氟康唑。
