2型糖尿病中的肥胖、过氧化物酶体增殖物激活受体与动脉粥样硬化
Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes.
作者信息
Blaschke Florian, Takata Yasunori, Caglayan Evren, Law Ronald E, Hsueh Willa A
机构信息
Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
出版信息
Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):28-40. doi: 10.1161/01.ATV.0000191663.12164.77. Epub 2005 Oct 20.
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. The 3 PPAR isotypes, PPAR-alpha, PPAR-gamma, and PPAR-delta, play a key role in the regulation of lipid and glucose metabolism. Obesity and the interrelated disorders of the metabolic syndrome have become a major worldwide health problem. In this review, we summarize the critical role of PPARs in regulating inflammation, lipoprotein metabolism, and glucose homeostasis and their potential implications for the treatment of obesity, diabetes, and atherosclerosis.
过氧化物酶体增殖物激活受体（PPARs）是属于核激素受体超家族的配体激活转录因子。3种PPAR亚型，即PPAR-α、PPAR-γ和PPAR-δ，在脂质和葡萄糖代谢调节中起关键作用。肥胖及代谢综合征的相关疾病已成为全球主要的健康问题。在本综述中，我们总结了PPARs在调节炎症、脂蛋白代谢和葡萄糖稳态中的关键作用及其对肥胖、糖尿病和动脉粥样硬化治疗的潜在意义。
Zotero 插件