Bage Isaac J, Kamalanathan Sadishkumar, Selvarajan Sandhiya, Sahoo Jayaprakash, Mathaiyan Jayanthi, Naik Dukhabandhu
Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Indian J Endocrinol Metab. 2023 Mar-Apr;27(2):118-126. doi: 10.4103/ijem.ijem_451_22. Epub 2023 Apr 14.
Peroxisome proliferator-activated receptors (PPAR) α and γ genes play an important role in dyslipidaemia of T2DM.
To estimate the frequency distribution of PPAR α and γ gene polymorphisms in South Indian T2DM patients with dyslipidaemia compared to healthy controls. Normative frequencies of SNPs were established and compared with data for 1000 genome populations.
Eligible 382 cases and 336 age and sex-matched controls were enrolled. Six SNPs in PPARα [rs1800206 C>G (Leu162Val), rs4253778 G>C, rs135542 T>C] and PPARγ [rs3856806 (C>T), rs10865710 (C>G), rs1805192 C>G (Pro12Ala)] genes were selected for genotyping.
The allele and gene frequencies did not significantly differ between the diabetic dyslipidaemia cases and healthy controls. However, they were significantly different from that of 1000 genome populations except for rs1800206 C>G (Leu162Val) and rs1805192 C>G (Pro12Ala).
The studied polymorphisms in PPARα and PPARγ genes are not associated with diabetic dyslipidaemia among South Indian patients.
过氧化物酶体增殖物激活受体（PPAR）α和γ基因在2型糖尿病血脂异常中起重要作用。
评估南印度血脂异常的2型糖尿病患者与健康对照相比，PPARα和γ基因多态性的频率分布。确定单核苷酸多态性（SNP）的标准频率，并与千人基因组群体的数据进行比较。
纳入382例符合条件的病例和336例年龄和性别匹配的对照。选择PPARα基因的6个SNP [rs1800206 C>G（Leu162Val）、rs4253778 G>C、rs135542 T>C]和PPARγ基因的6个SNP [rs3856806（C>T）、rs10865710（C>G）、rs1805192 C>G（Pro12Ala）]进行基因分型。
糖尿病血脂异常病例与健康对照之间的等位基因和基因频率无显著差异。然而，除rs1800206 C>G（Leu162Val）和rs1805192 C>G（Pro12Ala）外，它们与千人基因组群体的频率显著不同。
在南印度患者中，PPARα和γ基因的研究多态性与糖尿病血脂异常无关。
