Mitragotri Samir
Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA.
Nat Rev Immunol. 2005 Dec;5(12):905-16. doi: 10.1038/nri1728.
Most current immunization procedures make use of needles and syringes for vaccine administration. With the increase in the number of immunizations that children around the world routinely receive, health organizations are beginning to look for safer alternatives that reduce the risk of cross-contamination that arises from needle reuse. This article focuses on contemporary developments in needle-free methods of immunization, such as liquid-jet injectors, topical application to the skin, oral pills and nasal sprays.
目前大多数免疫接种程序都使用针头和注射器来接种疫苗。随着全球儿童常规接种疫苗数量的增加,卫生组织开始寻找更安全的替代方法,以降低因重复使用针头而产生交叉污染的风险。本文重点关注无针免疫接种方法的当代发展,如液体喷射注射器、皮肤局部用药、口服药丸和鼻喷雾剂。