Mizunuma H, Andoh K, Yamada K, Takagi T, Kamijo T, Ibuki Y
Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan.
Fertil Steril. 1992 Jul;58(1):46-50. doi: 10.1016/s0015-0282(16)55135-8.
To elucidate whether early detection of premature luteinizing hormone (LH) release can be useful for prediction and prevention of ovarian hyperstimulation during purified follicle-stimulating hormone (FSH) therapy.
Retrospective and prospective study.
Infertile women with polycystic ovarian syndrome.
Correlation between rate of endogenous LH release and incidence of excessive ovarian enlargement. In the prospective study, LH was measured by fluorometric enzyme immunoassay to obtain real-time concentration. Maximal ovarian diameter by ultrasonography.
The rate of excessive ovarian enlargement (greater than or equal to 60 mm) in cycles that were treated by a daily administration of purified FSH and accompanied by premature LH release was 83.3%. This rate was significantly higher than that in cycles without premature LH release (24.1%, P less than 0.001). Interruption of FSH administration or alternate day FSH administration in cycles with premature LH release reduced the rate of ovarian enlargement to 45.5% (P less than 0.05).
Early detection of premature LH release is useful for prediction of ovarian hyperstimulation. Ovarian hyperstimulation can be reduced by modulating the dose of FSH and the interval of administration in cycles with premature LH release.
阐明在纯化促卵泡激素（FSH）治疗期间，早期检测促黄体生成素（LH）过早释放是否有助于预测和预防卵巢过度刺激。
回顾性和前瞻性研究。
多囊卵巢综合征不孕女性。
内源性LH释放率与卵巢过度增大发生率之间的相关性。在前瞻性研究中，采用荧光酶免疫测定法测量LH以获得实时浓度。通过超声检查测量卵巢最大直径。
每日给予纯化FSH治疗且伴有LH过早释放的周期中，卵巢过度增大（大于或等于60mm）的发生率为83.3%。该发生率显著高于无LH过早释放的周期（24.1%，P<0.001）。在LH过早释放的周期中，中断FSH给药或隔日给予FSH可将卵巢增大率降低至45.5%（P<0.05）。
早期检测LH过早释放有助于预测卵巢过度刺激。通过在LH过早释放的周期中调整FSH剂量和给药间隔，可以降低卵巢过度刺激的发生。
