Mukherjee T, Copperman A B, Lapinski R, Sandler B, Bustillo M, Grunfeld L
Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, New York 10027, USA.
Fertil Steril. 1996 Mar;65(3):588-93. doi: 10.1016/s0015-0282(16)58159-x.
To determine if an elevated FSH:LH ratio predicts response in infertile patients undergoing controlled ovarian hyperstimulation (COH) for IVF-ET.
Retrospective study.
The Division of Reproductive Endocrinology at the Mount Sinai Medical Center, New York, New York.
Seventy-four patients undergoing IVF-ET using similar protocols for COH with day 3 FSH, LH, and E2 testing available for analysis. All patients were < 41 years of age and had day 3 serum FSH < 15 mIU/mL (conversion to SI unit, 1.00).
Follicle-stimulating hormone:LH ratio, day 8 serum E2, peak serum E2, cancellation rate, pregnancy rate, and number and size of follicles.
An FSH:LH ratio > or = 3.6 (group I) predicted a poor response to COH (sensitivity 85.7% and specificity 95%). There were no significant differences regarding day 3 serum FSH and ampules of gonadotropins used for COH. Group I (ratio > or = 3.6) patients responded to COH with lower day 8 E2 (97 +/- 18 versus 319 +/- 36 pg/mL; conversion factor to SI unit, 3.671), peak E2 (422 +/- 115 versus 2,368 +/- 183 pg/mL), and fewer follicles > 15 mm (1.3 +/- 0.5 versus 17.1 +/- 1.0). In group I the cycle cancellation rate (12/14) was significantly higher than the group II cycle cancellation rate (2/60) and pregnancy rate in group II (ratio < 3.6) was 25%.
The FSH:LH ratio may increase before a dramatic increase in serum FSH is observed and appears to be a useful marker of ovarian reserve.
确定升高的促卵泡激素（FSH）与促黄体生成素（LH）比值是否可预测接受体外受精-胚胎移植（IVF-ET）控制性卵巢刺激（COH）的不孕患者的反应。
回顾性研究。
纽约市西奈山医学中心生殖内分泌科。
74例接受IVF-ET的患者，采用相似的COH方案，且有第3天的FSH、LH和雌二醇（E2）检测结果可供分析。所有患者年龄均小于41岁，且第3天血清FSH<15 mIU/mL（换算为国际单位制，1.00）。
促卵泡激素与促黄体生成素比值、第8天血清E2、血清E2峰值、取消率、妊娠率以及卵泡数量和大小。
FSH:LH比值≥3.6（第I组）预示对COH反应不良（敏感性85.7%，特异性95%）。第3天血清FSH及用于COH的促性腺激素安瓿数无显著差异。第I组（比值≥3.6）患者对COH的反应为第8天E2较低（97±18对319±36 pg/mL；换算为国际单位制的转换系数为3.671）、E2峰值较低（422±115对2368±183 pg/mL）以及直径>15 mm的卵泡较少（1.3±0.5对17.1±1.0）。第I组的周期取消率（12/14）显著高于第II组（2/60），第II组（比值<3.6）的妊娠率为25%。
在血清FSH显著升高之前，FSH:LH比值可能升高，且似乎是卵巢储备的有用标志物。
