Dorchy H
Clinique de Diabétologie, Hôpital Universitaire des Enfants Reine Fabiola. Bruxelles.
Rev Med Brux. 2005 Sep;26(4):S246-54.
The increasing prevalence of type 2 diabetes in the USA has closely paralleled the increase in childhood obesity noted there, but now across the Western world and therefore in Belgium. (Pre)type 2 diabetes is preceded by insulin resistance which must be diagnosed and treated. In Belgium, type 1 diabetes is the predominant (97%) form of diabetes in young people (< 2,000 cases under the age of 18 years). Type 1 diabetes is an auto-immune disease which is more aggressive in younger children. At onset, the key-symptoms are : polyuria, polydipsia, weight loss, asthenia. Diagnosis is confirmed with 2 strips measuring glycaemia and glycosuria. Treatment and diabetes education for self-management should be initiated immediately in paediatric clinics of diabetology with a specialised multidisciplinary team. Thanks to the Belgian Social medicine, medical consultations and material necessary for treatment are nearly without cost. The principal aims of therapeutic management of the child, adolescent and adult with type 1 diabetes are to allow good quality of life and to avoid long-term complications by maintaining blood glucose concentrations close to the normal range and an HbA1c level under 7%. The number of daily insulin injections, 2 or > or = 4, by itself does not necessarily give better results, but the 4-injection regimen allows greater freedom, taking into account that the proper insulin adjustment is difficult before adolescence. Successful glycaemic control in young patients depends mainly on the quality and intensity of diabetes education. Any dogmatism must be avoided. Dietary recommendations issued over the last few years are the same for diabetic and non-diabetic individuals in order to avoid degenerative diseases. In the twice-daily injection regimen, the allocation of carbohydrates throughout the day is essential. Due to their pharmakokinetic characteristics, rapid-acting and long-acting insulin analogues have specific indications in both the twice-daily injection regimen and the basal-bolus insulin therapy. They improve quality of life, without necessarily reducing HbA1c.
在美国,2型糖尿病患病率的上升与儿童肥胖率的增加密切相关,如今这种现象在整个西方世界都存在,比利时也不例外。(前驱)2型糖尿病之前存在胰岛素抵抗,必须对其进行诊断和治疗。在比利时,1型糖尿病是年轻人中主要的(97%)糖尿病类型(18岁以下病例不到2000例)。1型糖尿病是一种自身免疫性疾病,在年幼儿童中更具侵袭性。发病时的主要症状为:多尿、多饮、体重减轻、乏力。通过两条检测血糖和糖尿的试纸即可确诊。应在糖尿病儿科诊所由专业多学科团队立即开展自我管理的治疗和糖尿病教育。多亏了比利时社会医学,医疗咨询和治疗所需材料几乎免费。对1型糖尿病儿童、青少年和成人进行治疗管理的主要目标是通过将血糖浓度维持在接近正常范围且糖化血红蛋白水平低于7%,实现良好的生活质量并避免长期并发症。每日胰岛素注射次数为2次或≥4次,其本身不一定能带来更好的效果,但考虑到青春期前难以进行适当的胰岛素调整,4次注射方案能带来更大的自由度。年轻患者血糖控制的成功主要取决于糖尿病教育的质量和强度。必须避免任何教条主义。过去几年发布的饮食建议对糖尿病患者和非糖尿病患者相同,以避免退行性疾病。在每日两次注射方案中,全天碳水化合物的分配至关重要。由于其药代动力学特性,速效和长效胰岛素类似物在每日两次注射方案和基础-餐时胰岛素治疗中都有特定的适应症。它们改善了生活质量,但不一定能降低糖化血红蛋白水平。