Burns James A, Zeitels Steven M, Anderson R Rox, Kobler James B, Pierce Mark C, de Boer Johannes F
Department of Surgery, Harvard Medical School, Boston, MA 02114, USA.
Ann Otol Rhinol Laryngol. 2005 Sep;114(9):671-6. doi: 10.1177/000348940511400903.
Discerning the layered microstructure of the vocal folds is critical for effective phonomicrosurgery. Optical coherence tomography (OCT), a noncontact, noninvasive technology that provides cross-sectional images by means of backscattered light, offers the potential for delineating these layers in vivo.
The glottal mucosa of 3 human cadaver larynges was imaged with conventional OCT and polarization-sensitive OCT (PS-OCT). Images were obtained through the epithelium and lamina propria.
Although the superficial layer of the lamina propria appeared quite homogeneous, the outer surface of the superficial lamina propria was correlated with an increase in backscatter with OCT. The superficial lamina propria and vocal ligament were correlated with a marked increase in tissue birefringence with PS-OCT.
This preliminary study demonstrates the capacity of OCT and PS-OCT for visualizing the layered microstructure of the vocal fold mucosa. We believe that these imaging techniques will have applications in the exploration of solutions to vocal fold scarring and in imaging vocal fold disorders in the clinic and operating room.
识别声带的分层微观结构对于有效的嗓音显微手术至关重要。光学相干断层扫描（OCT）是一种通过背向散射光提供横截面图像的非接触、非侵入性技术，具有在体内描绘这些层次的潜力。
使用传统OCT和偏振敏感OCT（PS - OCT）对3具人类尸体喉部的声门黏膜进行成像。图像通过上皮和固有层获取。
尽管固有层的表层看起来相当均匀，但固有层浅层的外表面与OCT背向散射的增加相关。固有层浅层和声带韧带与PS - OCT中组织双折射的显著增加相关。
这项初步研究证明了OCT和PS - OCT可视化声带黏膜分层微观结构的能力。我们相信这些成像技术将在探索声带瘢痕的解决方案以及在临床和手术室对声带疾病进行成像方面有应用价值。
