Rubinstein Marc, Fine Esther L, Sepehr Ali, Armstrong William B, Crumley Roger L, Kim Jason H, Chen Zhongping, Wong Brian J F
Department of Otolaryngology--Head and Neck Surgery and Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California, USA.
J Otolaryngol Head Neck Surg. 2010 Apr;39(2):150-6.
To present our experience using the first commercially available optical coherence tomography (OCT) device for use in the head, neck, and upper aerodigestive tract and to determine the feasibility and efficacy of this system in comparison with our previous experience using other research OCT systems.
Using the Niris OCT imaging system (Imalux, Cleveland, OH), we obtained OCT images of benign and premalignant laryngeal disease in 33 patients undergoing surgical head and neck endoscopy. This imaging system has a spatial depth resolution of 10 to 20 mum and a depth scanning range of 2.2 mm, obtaining images of 200 x 200 pixels at a maximum frame rate of 0.7 Hz. The scanning mechanism of the device is located at the distal end of a flexible probe that is placed in contact or near-contact with the area of interest. The tip of the probe was inserted through a rigid laryngoscope, and still images were obtained.
OCT images of arytenoids, aryepiglottic folds, piriform sinus, epiglottis, and true and false vocal cords were obtained. In patients whose OCT images were taken from normal tissue, the normal microstructures were clearly identified, as well as disruption of the latter in malignant pathologies.
The device can easily be incorporated into the operating room and requires minimal set-up and staff to operate. OCT imaging with this device potentially offers an efficient, quick, and reliable imaging modality in guiding surgical biopsies, intraoperative decision making, and therapeutic options of various laryngeal pathologies and premalignant disease.
介绍我们使用首款可用于头部、颈部及上呼吸道消化道的商用光学相干断层扫描（OCT）设备的经验，并与我们之前使用其他研究型OCT系统的经验相比较，以确定该系统的可行性和有效性。
我们使用Niris OCT成像系统（Imalux，俄亥俄州克利夫兰），对33例接受头颈外科内镜手术的患者的喉良性及癌前病变进行了OCT成像。该成像系统的空间深度分辨率为10至20微米，深度扫描范围为2.2毫米，以最高0.7赫兹的帧率获取200×200像素的图像。该设备的扫描机制位于一根柔性探头的远端，探头与感兴趣区域接触或近接触放置。探头尖端通过硬喉镜插入，并获取静态图像。
获得了杓状软骨、杓会厌襞、梨状窝、会厌以及真假声带的OCT图像。在从正常组织获取OCT图像的患者中，正常微观结构清晰可辨，而在恶性病变中则可看到这些结构的破坏。
该设备可轻松整合到手术室中，操作时所需的设置和人员极少。使用该设备进行OCT成像可能为指导手术活检、术中决策以及各种喉部病变和癌前疾病的治疗选择提供一种高效、快速且可靠的成像方式。
