基于天然HIV反式激活因子（Tat）蛋白以及Tat与HIV结构蛋白变体DeltaV2包膜糖蛋白（Env）组合的疫苗。
Vaccines based on the native HIV Tat protein and on the combination of Tat and the structural HIV protein variant DeltaV2 Env.
作者信息
Ensoli Barbara, Cafaro Aurelio, Caputo Antonella, Fiorelli Valeria, Ensoli Fabrizio, Gavioli Riccardo, Ferrantelli Flavia, Cara Andrea, Titti Fausto, Magnani Mauro
机构信息
AIDS National Center, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy.
出版信息
Microbes Infect. 2005 Nov;7(14):1392-9. doi: 10.1016/j.micinf.2005.07.016. Epub 2005 Sep 15.
The promising results obtained with the HIV-1 Tat-based vaccines in mice, monkeys and humans, a better understanding of Tat immunomodulatory functions, as well as evidence that vaccination with trimeric V2 loop-deleted HIV-1 Env induces cross-clade neutralizing antibodies led to the rational design of a novel vaccine based on the combination of Tat and V2-deleted Env.
基于HIV-1反式激活因子（Tat）的疫苗在小鼠、猴子和人类身上取得的有前景的结果，对Tat免疫调节功能的更好理解，以及三聚体V2环缺失的HIV-1包膜糖蛋白（Env）疫苗诱导跨亚型中和抗体的证据，促使人们合理设计出一种基于Tat和V2缺失Env组合的新型疫苗。
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