基于Nef以及基于Nef/DeltaV2 Env的疫苗。
Vaccines based on Nef and on Nef/DeltaV2 Env.
作者信息
Erfle Volker, Goebel Frank D, Guzman Carlos A, Le Grand Roger
机构信息
Institute of Molecular Virology, GSF-National Research Center for Environment and Health, Ingolstaedter Landstrasse 1a, 85764 Neuherberg, Germany.
出版信息
Microbes Infect. 2005 Nov;7(14):1400-4. doi: 10.1016/j.micinf.2005.07.015. Epub 2005 Sep 15.
PMID:16243564
Abstract
Modified vaccinia virus Ankara (MVA) is a potent vaccine vector, which proved its safety, immunogenity and efficacy in preclinical and clinical studies. The rational for the development of a vaccine against HIV based on the regulatory protein Nef delivered by MVA combined with a V2-deleted Env protein is discussed.
摘要
安卡拉痘苗病毒（MVA）是一种有效的疫苗载体，已在临床前和临床研究中证明了其安全性、免疫原性和有效性。本文讨论了基于MVA递送的调节蛋白Nef与缺失V2的Env蛋白联合开发抗HIV疫苗的原理。
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