基于多种HIV抗原的疫苗背后的基本原理。
The rationale behind a vaccine based on multiple HIV antigens.
作者信息
Rollman E, Bråve A, Boberg A, Gudmundsdotter L, Engström G, Isaguliants M, Ljungberg K, Lundgren B, Blomberg P, Hinkula J, Hejdeman B, Sandström E, Liu M, Wahren B
机构信息
Swedish Institute for Infectious Disease Control, Solna, Sweden.
出版信息
Microbes Infect. 2005 Nov;7(14):1414-23. doi: 10.1016/j.micinf.2005.07.017. Epub 2005 Sep 29.
The viral diversity of HIV-1 is likely to require a vaccine strategy that induces broad cellular and humoral anti-HIV-1 immunity. Our strategy is based on multiple HIV-1 DNA immunogens together with adjuvant recombinant granulocyte-macrophage stimulating factor. This article describes pre-clinical and clinical work preceding the initiation of clinical HIV-1 phase I/II trials.
HIV-1的病毒多样性可能需要一种能诱导广泛的细胞和体液抗HIV-1免疫的疫苗策略。我们的策略基于多种HIV-1 DNA免疫原以及佐剂重组粒细胞-巨噬细胞刺激因子。本文描述了在启动HIV-1临床I/II期试验之前的临床前和临床工作。
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