Morishita A, Mutoh N, Ishizawa K, Suzuki T, Yokoiyama S, Yaginuma S
Research Laboratories, Toyo Jozo Co., Ltd., Shizuoka, Japan.
J Antibiot (Tokyo). 1992 May;45(5):613-7. doi: 10.7164/antibiotics.45.613.
Sporeamicin A is a new erythromycin-type antibiotic isolated from a species of Saccharopolyspora. It was active in vitro against a wide variety of Gram-positive bacteria. In vitro studies indicated that the sporeamicin A was stable in the presence of human serum, although it was bound to serum proteins. Sporeamicin A was effective in the mouse protection test against Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Sporeamicin A attained higher plasma and tissue levels in the rat than did erythromycin stearate.
孢子霉素A是从一种糖多孢菌中分离出的新型红霉素类抗生素。它在体外对多种革兰氏阳性菌具有活性。体外研究表明，孢子霉素A在人血清存在下是稳定的，尽管它与血清蛋白结合。孢子霉素A在小鼠保护试验中对金黄色葡萄球菌、化脓性链球菌和肺炎链球菌有效。在大鼠体内，孢子霉素A的血浆和组织水平比硬脂酸红霉素更高。
