孢子霉素A，一种新型大环内酯类抗生素。I. 分类学、发酵、分离与表征

Sporeamicin A, a new macrolide antibiotic. I. Taxonomy, fermentation, isolation and characterization.

作者信息

Yaginuma S, Morishita A, Ishizawa K, Murofushi S, Hayashi M, Mutoh N

机构信息

Research Labolatories, Toyo Jozo Co., Ltd., Shizuoka, Japan.

出版信息

J Antibiot (Tokyo). 1992 May;45(5):599-606. doi: 10.7164/antibiotics.45.599.

DOI:10.7164/antibiotics.45.599

PMID:1624360

Abstract

Sporeamicin A, a novel antibiotic, was isolated from the culture filtrate of an actinomycete. The producing organism, strain L53-18, was taxonomically assigned as a species of the genus Saccaropolyspora. The antibiotic was extracted with chloroform and was then purified by crystallization. It was obtained as colorless prisms from ethanolic solutions. Sporeamicin A exhibited a strong UV absorption peak at 276 nm. The molecular formula of sporeamicin A was determined to be C37H63NO12.

摘要

孢子霉素A是一种新型抗生素，从一种放线菌的培养滤液中分离得到。产生该抗生素的菌株L53 - 18在分类学上被归为糖多孢菌属的一个种。该抗生素用氯仿萃取，然后通过结晶纯化。从乙醇溶液中得到无色棱柱体。孢子霉素A在276nm处呈现出强烈的紫外吸收峰。孢子霉素A的分子式确定为C37H63NO12。