一种新型抗蠕虫环缩肽，PF1022A。
A new anthelmintic cyclodepsipeptide, PF1022A.
作者信息
Sasaki T, Takagi M, Yaguchi T, Miyadoh S, Okada T, Koyama M
机构信息
Pharmaceutical Research Laboratories, Meiji Seika Kaisha Ltd., Yokohama, Japan.
出版信息
J Antibiot (Tokyo). 1992 May;45(5):692-7. doi: 10.7164/antibiotics.45.692.
The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (FERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-meth ylleucyl-D-lactyl-L-N- methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.
新型抗蠕虫环缩肽PF1022A是从无菌丝体PF1022（FERM BP - 2671）的培养菌丝体中分离得到的。它对鸡蛔虫显示出很强的驱虫活性。通过光谱分析和化学研究确定PF1022A的结构为环（D - 乳酰 - L - N - 甲基亮氨酰 - D - 3 - 苯丙酰 - L - N - 甲基亮氨酰 - D - 乳酰 - L - N - 甲基亮氨酰 - D - 3 - 苯丙酰 - L - N - 甲基亮氨酰）。
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