一些杆菌肽衍生物的合成与活性

Syntheses and activities of some bactobolin derivatives.

作者信息

Nishimura Y, Kondo S, Takeuchi T

机构信息

Institute of Microbial Chemistry, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1992 May;45(5):735-41. doi: 10.7164/antibiotics.45.735.

DOI:10.7164/antibiotics.45.735

PMID:1624375

Abstract

Some derivatives of bactobolin were prepared from bactobolin by dehydration or substitution reactions through tris(dimethylamino)alkoxyphosphonium salt formation. A derivative with low toxicity, 6-deoxybactobolin, showed moderate activity against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus.

摘要

通过三（二甲氨基）烷氧基鏻盐的形成，经脱水或取代反应从杆菌肽制备了一些杆菌肽衍生物。一种低毒衍生物，6-脱氧杆菌肽，对包括耐甲氧西林金黄色葡萄球菌在内的革兰氏阳性和革兰氏阴性细菌表现出中等活性。