基于C-3位官能团改变的杆菌肽衍生物的合成与活性
Synthesis and activities of bactobolin derivatives based on the alteration of the functionality at C-3 position.
作者信息
Adachi H, Usui T, Nishimura Y, Kondo S, Ishizuka M, Takeuchi T
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1998 Feb;51(2):184-8. doi: 10.7164/antibiotics.51.184.
PMID:9544940
Abstract
Some derivatives of bactobolin were prepared from bactobolin (1) by radical reduction and formation of the fused azetidine ring. The derivatives proved less active than the parent antibiotic 1 against bacteria, indicating that dichloromethyl group at C-3 position play an important role in biological activity.
摘要
通过自由基还原和稠合氮杂环丁烷环的形成，从杆菌肽（1）制备了一些杆菌肽衍生物。这些衍生物对细菌的活性比母体抗生素1低，表明C-3位的二氯甲基在生物活性中起重要作用。
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