Adachi H, Usui T, Nishimura Y, Kondo S, Ishizuka M, Takeuchi T
Institute of Microbial Chemistry, Tokyo, Japan.
J Antibiot (Tokyo). 1998 Feb;51(2):184-8. doi: 10.7164/antibiotics.51.184.
Some derivatives of bactobolin were prepared from bactobolin (1) by radical reduction and formation of the fused azetidine ring. The derivatives proved less active than the parent antibiotic 1 against bacteria, indicating that dichloromethyl group at C-3 position play an important role in biological activity.
通过自由基还原和稠合氮杂环丁烷环的形成，从杆菌肽（1）制备了一些杆菌肽衍生物。这些衍生物对细菌的活性比母体抗生素1低，表明C-3位的二氯甲基在生物活性中起重要作用。
