Regnier A, Cazalot G, Cantaloube B
Department of Clinical Sciences, National Veterinary School, 23 Chemin des Capelles, Toulouse Cedex 03, France.
Vet Rec. 2005 Oct 22;157(17):510-3. doi: 10.1136/vr.157.17.510.
The potential efficacy of topical epsilon-aminocaproic acid, an antiplasmin agent, in the treatment of persistent corneal epithelial defects was evaluated in a study of the medical records of 44 dogs, in which 51 eyes had been diagnosed with a corneal epithelial defect lasting more than 10 days, with no apparent underlying cause. At an initial examination all the affected eyes had had non-adherent epithelium removed. Thirty-four of the eyes in 28 dogs examined between January 2000 and March 2003 were also treated by the topical application of a solution of 35.7 mg/ml ophthalmic aminocaproic acid three times a day; the other 17 eyes in 16 dogs treated between October 1997 and March 1999 had received only topical treatment with gentamicin in addition to the debridement. Both groups were assessed clinically at weekly intervals for a maximum of three weeks. The two groups had approximately the same breed distribution, and there were no statistically significant differences between them in terms of their age, sex, affected side or duration of the corneal erosions. After three weeks, 32 of the 34 eyes treated with aminocaproic acid (94.1 per cent) had been cured, compared with seven of the 17 eyes treated with gentamicin (41.2 per cent) (P=0.0001). No adverse drug reactions were reported.
在一项对44只犬的病历研究中，评估了抗纤溶药物局部应用ε-氨基己酸治疗持续性角膜上皮缺损的潜在疗效。该研究中，51只眼睛被诊断为角膜上皮缺损持续超过10天，且无明显潜在病因。初次检查时，所有患眼均已去除未粘连的上皮。在2000年1月至2003年3月期间检查的28只犬的34只眼睛，还接受了每天3次局部应用35.7mg/ml眼科用氨基己酸溶液的治疗；在1997年10月至1999年3月期间治疗的16只犬的另外17只眼睛，除清创外仅接受了庆大霉素局部治疗。两组均每周进行一次临床评估，最长持续三周。两组的品种分布大致相同，在年龄、性别、患侧或角膜糜烂持续时间方面，两组之间无统计学显著差异。三周后，接受氨基己酸治疗的34只眼睛中有32只（94.1%）治愈，而接受庆大霉素治疗的17只眼睛中有7只（41.2%）治愈（P=0.0001）。未报告药物不良反应。
