Wu Doris, Smith Sara M, M Stine Jessica, M Michau Tammy, Miller Thomas R, Pederson Samantha L, Freeman Kate S
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.
Vet Ophthalmol. 2018 Nov;21(6):622-631. doi: 10.1111/vop.12556. Epub 2018 Mar 14.
To evaluate the efficacy of diamond burr debridement (DBD) vs a combination of diamond burr debridement with superficial grid keratotomy (DBD+SGK) for the treatment of spontaneous chronic corneal epithelial defects (SCCEDs) in dogs.
Medical records of dogs diagnosed with SCCEDs from three different institutions that received a DBD or DBD+SGK between 2003 and 2015 were reviewed. Age, breed, sex, history of a previous SCCED, procedures performed, time to healing, and complications were statistically analyzed.
One hundred and ninety-four dogs met the inclusion criteria. Eighty-two of 106 eyes (77.4%) received a DBD and healed following the first treatment (13.3 ± 4.9 days to recheck, range 2-27). Sixty-eight of 88 eyes (77.3%) received a DBD+SGK and healed following the first treatment (15.4 ± 5.0 days to recheck, range 5-45). No significant difference in healing outcome was found between the two treatments (P = 1). For SCCEDs that healed after a single treatment (n = 150), complications occurred in 13.3% (n = 20) of eyes with no difference in complications between the DBD and DBD+SGK groups (P = .86). Thirty-five of 44 eyes (80.0%) healed after the second treatment (16 ± 8.2 days from second treatment to third visit, range 5-47); nine of 44 eyes (20.0%) were not healed (12 ± 6.2 days from second treatment to third visit, range 5-25). The second treatment method did not influence healing rates (P = .64).
DBD and DBD+SGK are equally effective treatment methods for canine SCCEDs. No differences in complication rates after one treatment were observed between DBD and DBD+SGK.
评估金刚石磨头清创术(DBD)与金刚石磨头清创术联合浅表网格角膜切开术(DBD+SGK)治疗犬自发性慢性角膜上皮缺损(SCCEDs)的疗效。
回顾了2003年至2015年间来自三个不同机构诊断为SCCEDs并接受DBD或DBD+SGK治疗的犬只的病历。对年龄、品种、性别、既往SCCED病史、所行手术、愈合时间和并发症进行了统计分析。
194只犬符合纳入标准。106只眼中的82只(77.4%)接受了DBD治疗,并在首次治疗后愈合(复查时间为13.3±4.9天,范围为2-27天)。88只眼中的68只(77.3%)接受了DBD+SGK治疗,并在首次治疗后愈合(复查时间为15.4±5.0天,范围为5-45天)。两种治疗方法在愈合结果上无显著差异(P=1)。对于单次治疗后愈合的SCCEDs(n=150),13.3%(n=20)的眼出现并发症,DBD组和DBD+SGK组在并发症方面无差异(P=0.86)。44只眼中的35只(80.0%)在第二次治疗后愈合(从第二次治疗到第三次就诊的时间为16±8.2天,范围为5-47天);44只眼中的9只(20.0%)未愈合(从第二次治疗到第三次就诊的时间为12±6.2天,范围为5-25天)。第二种治疗方法不影响愈合率(P=0.64)。
DBD和DBD+SGK是治疗犬SCCEDs的同等有效治疗方法。DBD和DBD+SGK在单次治疗后的并发症发生率上无差异。