Pino Anna, Brescianini Sonia, D'Ippolito Cristina, Fagnani Corrado, Alimonti Alessandro, Stazi Maria Antonietta
Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy.
Ann Ist Super Sanita. 2005;41(2):223-8.
Quantification of 26 elements was performed in blood of patients affected by neurodegenerative pathologies, i.e., Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS), and of a control group to study the potential role of blood elements as markers for the different neurodegenerations. A multivariate discriminant analysis (stepwise method) was applied to determine the best set of variables to discriminate among subjects with different health status. Preliminary results show three classification functions of seven elements, namely Ca, Co, Cu, Fe, Ni, Pb and Zr.
对患有神经退行性疾病（即阿尔茨海默病（AD）、帕金森病（PD）和多发性硬化症（MS））的患者以及对照组的血液进行了26种元素的定量分析，以研究血液元素作为不同神经退行性疾病标志物的潜在作用。应用多元判别分析（逐步法）来确定区分不同健康状况受试者的最佳变量集。初步结果显示了七种元素（即钙、钴、铜、铁、镍、铅和锆）的三个分类函数。
