Başkol Mevlüt, Başkol Gülden, Deniz Kemal, Ozbakir Omer, Yücesoy Mehmet
Department of Gastroenterology, School of Medicine, Erciyes University, Kayseri, Turkey.
Turk J Gastroenterol. 2005 Sep;16(3):119-23.
BACKGROUND/AIMS: Relationship between hepatic antioxidant paraoxonase 1 (PON1) activity, lipid peroxidation and liver injury was investigated in patients with non-alcoholic steatohepatitis.
A total of 23 patients with non-alcoholic steatohepatitis (15 males, 8 females; mean age: 40.30+/-7.67 yrs) and 23 healthy controls (14 males, 9 females; mean age: 39.70+/- 8.78 yrs) were enrolled in the study. Serum paraoxonase 1 activity and levels of a well-known lipid peroxidation marker, serum malondialdehyde, were determined.
Serum paraoxonase 1 activity decreased significantly in non-alcoholic steatohepatitis compared to the control group (p<0.01). Serum malondialdehyde levels were significantly higher in patients with non-alcoholic steatohepatitis as compared with the control group (p<0.05). No statistically significant correlations were found between serum paraoxonase 1 activities and the grade-stage of non-alcoholic steatohepatitis, serum lipid levels or serum malondialdehyde levels (p>0.05).
Increased lipid peroxidation may be either a cause or a result of liver injury in patients with non-alcoholic steatohepatitis. Although serum paraoxonase 1 activity does not reflect the degree of liver damage in non-alcoholic steatohepatitis, reduced paraoxonase 1 activity, especially in the presence of mild disease, could be interpreted as a biochemical marker of the lipid peroxidation.
背景/目的：研究非酒精性脂肪性肝炎患者肝脏抗氧化对氧磷酶1（PON1）活性、脂质过氧化与肝损伤之间的关系。
本研究共纳入23例非酒精性脂肪性肝炎患者（男性15例，女性8例；平均年龄：40.30±7.67岁）和23例健康对照者（男性14例，女性9例；平均年龄：39.70±8.78岁）。测定血清对氧磷酶1活性以及一种著名的脂质过氧化标志物血清丙二醛的水平。
与对照组相比，非酒精性脂肪性肝炎患者血清对氧磷酶1活性显著降低（p<0.01）。与对照组相比，非酒精性脂肪性肝炎患者血清丙二醛水平显著升高（p<0.05）。血清对氧磷酶1活性与非酒精性脂肪性肝炎的分级分期、血脂水平或血清丙二醛水平之间未发现统计学显著相关性（p>0.05）。
脂质过氧化增加可能是非酒精性脂肪性肝炎患者肝损伤的原因或结果。虽然血清对氧磷酶1活性不能反映非酒精性脂肪性肝炎患者的肝损伤程度，但对氧磷酶1活性降低，尤其是在轻度疾病存在时，可被解释为脂质过氧化的生化标志物。
