Akdas Sevginur, Yazihan Nuray
Department of Metabolism and Clinical Nutrition, Institute of Health Sciences, Interdisciplinary Food, Ankara University, Ankara, Turkiye.
Department of Pathophysiology, Ankara University School of Medicine, Ankara, Turkiye.
Hepatol Forum. 2024 Jul 2;5(3):126-138. doi: 10.14744/hf.2023.2023.0042. eCollection 2024.
Non-alcoholic Fatty Liver Disease (NAFLD) is both a cause and a consequence of metabolic disturbances. Consequently, the disease term has recently changed to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Turkiye is one of the leading countries with high incidences of diseases such as diabetes, obesity, metabolic syndrome, and fatty liver. This study aims to identify the metabolic parameters and MASLD potential of NAFLD in Turkiye. All NAFLD studies conducted in Turkiye were systematically searched using the keywords "fatty liver disease" AND " Turkiye " on PubMed, Scopus, and Web of Science databases. A total of 2653 articles were scanned, and 120 studies were eligible for meta-analysis. The metabolic parameters were meta-analyzed from a broad perspective. According to the meta-analysis results, there were significant increases in waist circumferences (mean difference: 10.90, p<0.00001), HOMA-IR (mean difference: 2.13, p<0.00001), aspartate aminotransferase (AST) (mean difference: 17.82, p<0.00001), systolic blood pressure (SBP) (mean difference: 5.86, p<0.00001), and C-reactive protein (CRP) levels (mean difference: 0.95, p<0.00001). These parameters are representative biochemical findings of disturbed glucose metabolism, lipid profile, blood pressure, and acute phase response mechanisms. Furthermore, the analysis of all related parameters commonly found among the articles confirmed these metabolic dysfunctions. NAFLD is a metabolic disease that encompasses multiple pathways related to glucose and lipid metabolism, vascular function, inflammation, and acute phase responses. Additionally, our results suggest that Turkish NAFLD patients identified in previous studies mostly have MASLD. This is the first meta-analysis study indicating changes in metabolism-related parameters with a cumulative meta-analysis of all Turkish NAFLD studies.
非酒精性脂肪性肝病（NAFLD）既是代谢紊乱的一个原因，也是其结果。因此，该疾病术语最近已改为代谢功能障碍相关脂肪性肝病（MASLD）。土耳其是糖尿病、肥胖症、代谢综合征和脂肪肝等疾病高发的主要国家之一。本研究旨在确定土耳其NAFLD的代谢参数和发生MASLD的可能性。在PubMed、Scopus和Web of Science数据库中使用关键词“脂肪性肝病”和“土耳其”对土耳其进行的所有NAFLD研究进行了系统检索。共筛选了2653篇文章，120项研究符合荟萃分析的条件。从广泛的角度对代谢参数进行了荟萃分析。根据荟萃分析结果，腰围（平均差值：10.90，p<0.00001）、HOMA-IR（平均差值：2.13，p<0.00001）、天冬氨酸转氨酶（AST）（平均差值：17.82，p<0.00001）、收缩压（SBP）（平均差值：5.86，p<0.00001）和C反应蛋白（CRP）水平（平均差值：0.95，p<0.00001）均有显著升高。这些参数是葡萄糖代谢、血脂谱、血压和急性期反应机制紊乱的典型生化表现。此外，对文章中常见的所有相关参数的分析证实了这些代谢功能障碍。NAFLD是一种代谢性疾病，涉及与葡萄糖和脂质代谢、血管功能、炎症和急性期反应相关的多种途径。此外，我们的结果表明，先前研究中确定的土耳其NAFLD患者大多患有MASLD。这是第一项通过对所有土耳其NAFLD研究进行累积荟萃分析来表明代谢相关参数变化的荟萃分析研究。
