Rodriguez Garcia M, Naves Diaz M, Cannata Andia J B
Bone and Mineral Research Unit, Instituto Reina Sofia de Investigacion, Hospital Universitario Central de Asturias, Oviedo - Spain.
J Nephrol. 2005 Jul-Aug;18(4):458-63.
Bone and cardiovascular disorders are common age-related disorders in the general population and also in patients suffering from chronic kidney disease (CKD). Recent studies have shown an association between these two disorders and the rate of mortality. This article addresses some limitations of the concept of osteoporosis in CKD and compares bone and vascular disorders and mortality between non-selected general population and dialysis patients from the same geographic area. In the general population, all metabolic disorders increase with age, as well as vascular calcifications. The progression of vascular calcification was associated with a higher prevalence and incidence of bone fractures. In addition, both vascular calcifications and vertebral fractures were associated with higher mortality. A similar pattern was observed in dialysis patients with no increments in vertebral fractures, although with higher prevalence of vascular calcifications also both associated with higher mortality. Age was the strongest variable associated with all the analysed parameters, but some of the associations remained significant after age adjustment indicating the likely role of other common factors in the pathogenesis of bone and vascular disorders.
骨骼和心血管疾病在普通人群以及慢性肾脏病（CKD）患者中都是常见的与年龄相关的疾病。最近的研究表明这两种疾病与死亡率之间存在关联。本文探讨了CKD中骨质疏松概念的一些局限性，并比较了非特定普通人群与来自同一地理区域的透析患者的骨骼和血管疾病及死亡率。在普通人群中，所有代谢紊乱以及血管钙化都随年龄增加。血管钙化的进展与更高的骨折患病率和发病率相关。此外，血管钙化和椎体骨折都与更高的死亡率相关。在透析患者中也观察到了类似的模式，尽管椎体骨折没有增加，但血管钙化的患病率更高，且两者也都与更高的死亡率相关。年龄是与所有分析参数相关的最强变量，但在年龄调整后，一些关联仍然显著，这表明其他常见因素在骨骼和血管疾病的发病机制中可能发挥作用。
