Kiricuta I C, Kölbl O, Willner J, Bohndorf W
Clinic and Policlinic for Radiotherapy, University of Würzburg, Federal Republic of Germany.
J Cancer Res Clin Oncol. 1992;118(7):542-6. doi: 10.1007/BF01225270.
Sixty-two breast cancer patients with central nervous system (CNS) metastases were reviewed. The CNS was the first site of metastatic involvement in 38 cases (61%). The median survival from the primary diagnosis was 3.0 years; from the diagnosis of the CNS metastasis, 6 months. The interval between primary diagnosis and CNS metastasis had a median value of 2.0 years; between the initial extra-cranial metastasis and CNS metastasis this was 0.9 years. Prognostic factors for the appearance of CNS metastasis could not be identified. Subsequent to CNS metastasis appearing, the well-known prognostic factors for the survival time and the metastasis-free interval lose their importance. Brain metastases occur, above all, in patients aged between 50 and 55 years, very often in the first 2.5 years after the first distant metastasis and not later than 10 years from the primary diagnosis.
对62例发生中枢神经系统（CNS）转移的乳腺癌患者进行了回顾性研究。在38例（61%）患者中，CNS是转移累及的首个部位。从初次诊断开始计算的中位生存期为3.0年；从中枢神经系统转移诊断开始计算为6个月。初次诊断与中枢神经系统转移之间的间隔中位值为2.0年；初次颅外转移与中枢神经系统转移之间的间隔为0.9年。无法确定中枢神经系统转移出现的预后因素。中枢神经系统转移出现后，众所周知的生存时间和无转移间期的预后因素就失去了重要性。脑转移主要发生在年龄在50至55岁之间的患者中，通常在首次远处转移后的头2.5年内，且不晚于初次诊断后的10年。
