Simionescu Cristiana, Birău Carmen
Disciplina Morfopatologie, UMF Craiova.
Oftalmologia. 2005;49(2):104-12.
The aim of this paper is to study the morphopathological changes manifested in age-related macular degeneration.
The researched histopathological material consisted in two eye balls enucleated because of irreversible eye diseases from aged persons suffering from age-related macular degeneration. The method applied for processing the material was inclusion in paraffin, followed by usual coloration with hematoxylin-eosin.
The established changes (hard drusen, soft drusen, calcified drusen, changes of Bruch's membrane, subretinal neovascularization, serous retinal pigment epithelial detachment, disciform degeneration) prove the importance of Bruch's membrane in the pathogenesis of age-related macular degeneration.
本文旨在研究年龄相关性黄斑变性所表现出的形态病理学变化。
所研究的组织病理学材料包括因不可逆眼病而摘除的两只眼球,这些眼病来自患有年龄相关性黄斑变性的老年人。处理材料的方法是将其包埋于石蜡中,随后用苏木精-伊红进行常规染色。
所确定的变化(硬性玻璃膜疣、软性玻璃膜疣、钙化玻璃膜疣、布鲁赫膜的变化、视网膜下新生血管形成、浆液性视网膜色素上皮脱离、盘状变性)证明了布鲁赫膜在年龄相关性黄斑变性发病机制中的重要性。