[年龄相关性黄斑变性患者眼中玻璃膜疣的特征及 Bruch 膜的变化。组织学研究]
[Characteristics of drusen and changes in Bruch's membrane in eyes with age-related macular degeneration. Histological study].
作者信息
Spraul C W, Lang G E, Grossniklaus H E, Lang G K
机构信息
Universitäts-Augenklinik, Ulm.
出版信息
Ophthalmologe. 1998 Feb;95(2):73-9. doi: 10.1007/s003470050240.
BACKGROUND
Different types of drusen and changes in Bruch's membrane have been associated with age-related macular degeneration (AMD).
METHODS
We compared 51 eyes with different stages of AMD with 40 age-matched controls using light microscopy. The degree of calcification of Bruch's membrane, fragmentation of Bruch's membrane, number of different types of drusen, and basal laminar deposit (BLD) were assessed.
RESULTS
In the macular area, the presence of basal laminar deposit was most strongly associated with the presence of AMD. There was a statistically significant difference observed in the degree of calcification and fragmentation of Bruch's membrane in eyes with AMD as compared to controls. Eyes with AMD displayed significantly more soft, confluent, and large drusen as compared to controls.
CONCLUSION
Calcification and fragmentation of Bruch's membrane, soft, confluent, and large drusen and BLD but not hard drusen correlated strongly with the histologic presence of AMD. Calcification and fragmentation of Bruch's membrane seem to facilitate ingrowth of choroidal neovascular membranes with consecutive development of exudative AMD.
背景
不同类型的玻璃膜疣以及 Bruch 膜的改变与年龄相关性黄斑变性（AMD）有关。
方法
我们使用光学显微镜对 51 只处于不同 AMD 阶段的眼睛与 40 只年龄匹配的对照眼睛进行了比较。评估了 Bruch 膜的钙化程度、Bruch 膜的破碎情况、不同类型玻璃膜疣的数量以及基底膜沉积物（BLD）。
结果
在黄斑区，基底膜沉积物的存在与 AMD 的存在关联最为密切。与对照相比，AMD 患者眼睛中 Bruch 膜的钙化程度和破碎情况存在统计学上的显著差异。与对照相比，AMD 患者的眼睛显示出明显更多的软性、融合性和大的玻璃膜疣。
结论
Bruch 膜的钙化和破碎、软性、融合性和大的玻璃膜疣以及 BLD，但不是硬性玻璃膜疣，与 AMD 的组织学表现密切相关。Bruch 膜的钙化和破碎似乎促进脉络膜新生血管膜的生长，并随之发展为渗出性 AMD。
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