[Methodological studies on selectively removing toxins in Aristolochiae manshuriensis by chinese processing techniques].
作者信息
Wang Zhi-min, You Li-shuang, Jiang Xu, Li Lin, Wang Wei-hao, Wang Guan
机构信息
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2005 Aug;30(16):1243-6.
OBJECTIVE
To investigate the possibility of selectively detoxifying aristolochic acids in Aristolochiae manshuriensis (Guanmutong) by the chemical properties of aristolochic acids and traditional Chinese processing experience.
METHOD
The technical parameters in processing technique of A. manshuriensis were optimized by orthogonal designed methods with aristolochic acid A.
RESULT
The processing technique was soaked in 0.1 mol x L(-1) baking soda for several times and then processing with vinegar. Temperature was important factor to detoxify aristolochic acids. aristolochic acid A were removed over 90% from A. manshuriensis in laboratory and over 80% in medium-scale production by 10 batches from two origins of botanical drugs with different contents, and decreased to 0.35-0.60 mg x g(-1) in processed products. aristolochic acid A existed mostly salt-forms in the botanical drug.
CONCLUSION
Most toxic components in Guanmutong could be removed by the new processing method.
Zotero 插件