Shen Yun-hui, Chen Chang-xun, Xu Zhen-ye
Department of Pharmacology, Shanghai University of Traditional Chinese Madicine, Shanghai 201203, China.
Zhongguo Zhong Yao Za Zhi. 2005 Aug;30(16):1275-9.
To observe the effect of Shuanghuang Shengbai granule on mice leukopenia induced by ip cyclophosphamide (CTX) or radiation.
Mice leukopenia models were induced by ip CTX or radiation, and then treated with Shuanghuang Shengbai granule per oral. The peripheral hemogram, thymus index, spleen index, bone marrow nucleated cell (BMNC) and colony forming unit-spleen (CFU-S) were detected. The bone marrow cell differentiation was examined. The pathological slices of bone marrow were observed.
Shuanghuang Shengbai granule could increase the WBC, BMNC, CFU-S of model mice significantly; Shuanghuang Shengbai granule could make the granulocyte and erythrocyte index recovered to normal level and it could also protect the bone marrow hemotopoietic microenvironment from the harm of radiation.
Shuanghuang Shengbai granule has apparent leukogenic function.
观察双黄升白颗粒对环磷酰胺（CTX）腹腔注射或辐射所致小鼠白细胞减少症的影响。
采用CTX腹腔注射或辐射诱导小鼠白细胞减少症模型，然后灌胃给予双黄升白颗粒。检测外周血象、胸腺指数、脾脏指数、骨髓有核细胞（BMNC）和脾集落形成单位（CFU-S）。检查骨髓细胞分化情况。观察骨髓病理切片。
双黄升白颗粒可显著提高模型小鼠的白细胞、BMNC、CFU-S；双黄升白颗粒可使粒细胞和红细胞指数恢复至正常水平，还可保护骨髓造血微环境免受辐射损伤。
双黄升白颗粒具有明显的升白作用。
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