PTEN对细胞迁移的调控

The regulation of cell migration by PTEN.

作者信息

Leslie N R, Yang X, Downes C P, Weijer C J

机构信息

Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, Scotland, UK.

出版信息

Biochem Soc Trans. 2005 Dec;33(Pt 6):1507-8. doi: 10.1042/BST0331507.

DOI:10.1042/BST0331507

PMID:16246156

Abstract

In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.

摘要

在脊椎动物中，肿瘤抑制因子PTEN（第10号染色体缺失的磷酸酶和张力蛋白同源物）通过其磷脂酰肌醇-3,4,5-三磷酸（PtdIns(3,4,5)P3）脂质磷酸酶活性调节许多细胞过程，拮抗磷脂酰肌醇-3激酶（PI3K）信号传导。鉴于PI3K在定向细胞迁移调节中的重要作用以及PTEN作为迁移抑制剂的作用，现在的数据表明PTEN能够独立于其脂质磷酸酶活性调节细胞迁移，这有点令人惊讶。在这里，我们讨论PTEN在细胞迁移调节中的作用。