Rivers Emanuel P, McIntyre Lauralyn, Morro David C, Rivers Kandis K
Department of Emergency Medicine, Henry Ford Hospital, Detroit, Mich, USA.
CMAJ. 2005 Oct 25;173(9):1054-65. doi: 10.1503/cmaj.050632.
The pathogenic, diagnostic and therapeutic landscape of sepsis is no longer confined to the intensive care unit: many patients from other portals of entry to care, both outside and within the hospital, progress to severe disease. Approaches that have led to improved outcomes with other diseases (e.g., acute myocardial infarction, stroke and trauma) can now be similarly applied to sepsis. Improved understanding of the pathogenesis of severe sepsis and septic shock has led to the development of new therapies that place importance on early identification and aggressive management. This review emphasizes approaches to the early recognition, diagnosis and therapeutic management of sepsis, giving the clinician the most contemporary and practical approaches with which to treat these patients.
脓毒症的致病、诊断和治疗领域不再局限于重症监护病房：许多来自医院内外其他就医途径的患者会发展为重症疾病。在其他疾病（如急性心肌梗死、中风和创伤）中已带来改善预后效果的方法，现在同样可应用于脓毒症。对严重脓毒症和脓毒性休克发病机制的深入理解，促使了重视早期识别和积极管理的新疗法的发展。本综述强调脓毒症的早期识别、诊断和治疗管理方法，为临床医生提供治疗这些患者的最现代且实用的方法。
