Zani D, Simeone C, Cosciani Cunico S, da Pozzo G P
Divisione Clinicizzata di Urologia, Università degli Studi di Brescia, Brescia, Italy.
Minerva Urol Nefrol. 2005 Dec;57(4):335-9.
The results of a clinical investigation on neoplasm and bladder dysplasia detection by 5-aminolaevulinic acid (5-ALA)-induced fluorescence are reported. In this paper the authors report their experience with 5-ALA in the diagnosis, treatment and follow-up of bladder neoplasms after chemotherapy and endocavitary immunotherapy.
The 5-ALA was instilled in the bladder 2 h before bladder transurethral resection. This method has been used since December 2000 on 163 patients and a total of 266 biopsies were histologically examined.
One-hundred and four benign and 92 malignant/dysplastic areas were biopsied; 46 malignant/dysplastic lesions were not detected during routine white-light cystoscopy but were identified with fluorescence cystoscopy. Sensitivity was 99% but specificity was low (20%).
ALA-based fluorescence cystoscopy is a safe and simple technique that enhances the detection of flat and papillary urothelial neoplasms.
报告一项关于通过5-氨基乙酰丙酸（5-ALA）诱导荧光检测肿瘤和膀胱发育异常的临床研究结果。在本文中，作者报告了他们使用5-ALA进行化疗和腔内免疫治疗后膀胱肿瘤诊断、治疗及随访的经验。
在经尿道膀胱切除术2小时前将5-ALA注入膀胱。自2000年12月起，该方法已应用于163例患者，共266份活检标本进行了组织学检查。
共活检了104个良性区域和92个恶性/发育异常区域；46个恶性/发育异常病变在常规白光膀胱镜检查中未被发现，但在荧光膀胱镜检查中得以识别。敏感性为99%，但特异性较低（20%）。
基于ALA的荧光膀胱镜检查是一种安全、简单的技术，可提高扁平及乳头状尿路上皮肿瘤的检测率。
