聚（L-赖氨酸）接枝葡聚糖共聚物与2'-O，4'-C-亚甲基桥连核酸（2',4'-BNA）修饰的组合在中性pH下协同稳定嘧啶基序三链体。 - Suppr

Combination of poly(L-lysine)-graft-dextran copolymer and 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) modification synergistically stabilizes pyrimidine motif triplex at neutral pH.

作者信息

Torigoe Hidetaka, Katayama Takuma, Obika Satoshi, Maruyama Atushi, Imanishi Takeshi

机构信息

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):635-8. doi: 10.1081/ncn-200060113.

DOI:10.1081/ncn-200060113

PMID:16248002

Abstract

摘要

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Combination of poly(L-lysine)-graft-dextran copolymer and 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) modification synergistically stabilizes pyrimidine motif triplex at neutral pH.聚（L-赖氨酸）接枝葡聚糖共聚物与2'-O，4'-C-亚甲基桥连核酸（2',4'-BNA）修饰的组合在中性pH下协同稳定嘧啶基序三链体。

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):635-8. doi: 10.1081/ncn-200060113.

Synergistic stabilization of triplex by combination of comb-type cationic copolymer and 2',4'-BNA.梳型阳离子共聚物与2',4'-BNA组合对三链体的协同稳定作用

Nucleic Acids Symp Ser (Oxf). 2004(48):139-40. doi: 10.1093/nass/48.1.139.

Synergistic stabilization of nucleic acid assembly by 2'-O,4'-C-methylene-bridged nucleic acid modification and additions of comb-type cationic copolymers.通过2'-O,4'-C-亚甲基桥连核酸修饰和添加梳型阳离子共聚物实现核酸组装的协同稳定作用。

Biochemistry. 2009 Apr 21;48(15):3545-53. doi: 10.1021/bi801795z.

Inhibition of sequence-specific protein-DNA interaction and restriction endonuclease cleavage via triplex stabilization by poly(L-lysine)-graft-dextran copolymer.通过聚（L-赖氨酸）-接枝-葡聚糖共聚物稳定三链体来抑制序列特异性蛋白质-DNA相互作用和限制内切酶切割

Biomacromolecules. 2000 Summer;1(2):186-93. doi: 10.1021/bm9900141.

2'-O,4'-C-methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH: thermodynamic and kinetic studies.2'-O,4'-C-亚甲基桥连核酸修饰在生理pH条件下促进嘧啶基序三链DNA形成：热力学和动力学研究

J Biol Chem. 2001 Jan 26;276(4):2354-60. doi: 10.1074/jbc.M007783200. Epub 2000 Oct 16.

Poly(L-lysine)-graft-dextran copolymer: amazing effects on triplex stabilization under physiological pH and ionic conditions (in vitro).聚（L-赖氨酸）接枝葡聚糖共聚物：在生理pH和离子条件下（体外）对三链体稳定化具有惊人效果。

Nucleic Acids Res. 1998 Sep 1;26(17):3949-54. doi: 10.1093/nar/26.17.3949.

Synergistic stabilization of triplex by combination of comb-type cationic copolymer and oligo-N3'-->P5' phosphoramidates.梳型阳离子共聚物与寡聚-N3'→P5'亚磷酰胺酯组合对三链体的协同稳定作用。

Nucleic Acids Res Suppl. 2001(1):195-6. doi: 10.1093/nass/1.1.195.

Promotion of triplex formation by 3'-amino-2'-O,4'-C-methylene bridged nucleic acid modification.通过3'-氨基-2'-O,4'-C-亚甲基桥连核酸修饰促进三链体形成。

Nucleic Acids Symp Ser (Oxf). 2009(53):159-60. doi: 10.1093/nass/nrp080.

Interrupted 2'-o,4'-C-aminomethylene bridged nucleic acid modification enhances pyrimidine motif triplex-forming ability and nuclease resistance under physiological condition.2'-O,4'-C-氨基亚甲基桥连核酸的间断修饰增强了嘧啶基序在生理条件下形成三链体的能力和核酸酶抗性。

Nucleosides Nucleotides Nucleic Acids. 2011 Jan;30(1):63-81. doi: 10.1080/15257770.2010.543118.

Promotion of triplex formation by 2'-O,4'-C-aminomethylene bridged nucleic acid (2',4'-BNA NC) modification.通过2'-O,4'-C-氨基亚甲基桥连核酸（2',4'-BNA NC）修饰促进三链体形成。

Nucleic Acids Symp Ser (Oxf). 2008(52):419-20. doi: 10.1093/nass/nrn213.

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Combination of poly(L-lysine)-graft-dextran copolymer and 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) modification synergistically stabilizes pyrimidine motif triplex at neutral pH.

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