用于前药目的的核苷硼烷磷酰胺与氨基酸的模型合成。
Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose.
作者信息
Li Ping, Shaw Barbara Ramsay
机构信息
Department of Chemistry, Duke University, Box 90346, Durham, NC 27708-0346, USA.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):675-8. doi: 10.1081/ncn-200060244.
PMID:16248012
Abstract
A model synthesis of a nucleoside boranophosphoramidate prodrug with (L)-tryptophan methyl ester was accomplished in a one-pot reaction via an H-phosphonate approach. This new type of compound is expected to possess the potent antiviral and anticancer advantages conferred by boranophosphates and normal nucleoside amino acid phosphoramidate.
摘要
通过H-膦酸酯法，在一锅反应中完成了核苷硼烷磷酰胺前药与（L）-色氨酸甲酯的模型合成。这种新型化合物有望具备硼烷磷酸盐和普通核苷氨基酸磷酰胺所赋予的强大抗病毒和抗癌优势。
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