Rapid access to 2'-branched-carbocyclic nucleosides and their 4'-epimers from 2-alkyl-cyclopentene-1-ones.
作者信息
Meillon J C, Griffe L, Storer R, Gosselin G
机构信息
Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, Montpellier Cedex 5, France.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):695-9. doi: 10.1081/ncn-200060271.
PMID:16248017
Abstract
2-Methyl-2-cyclopentene-1-one was used as starting material in a novel route toward 2'-branchedcarbocyclic nucleosides. This methodology was efficiently adapted to the preparation of 4'-epicarbocycles. A series of this new class of molecules was synthesized as potential antiviral compounds.
摘要
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