Stereoselective synthesis of novel thioiso dideoxy nucleosides with exocyclic methylene as potential antiviral agents.

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作者信息

Gunaga Prashantha, Kim Hea Ok, Kim Hyun Ji, Chun Moon Woo, Jeong Lak Shin

机构信息

Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, Korea.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):1115-7. doi: 10.1081/ncn-200060072.

DOI:10.1081/ncn-200060072

PMID:16248103

Abstract

Novel thioiso pyrimidine and purine nucleosides substituted with exocyclic methylene have been synthesized, starting from D-xylose. Cyclization of the dimesylate to the 4-thiosugar 6a proceeded in pure SN2 reaction in the presence of allylic functional group.

摘要

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