药学上有用的非天然2'-脱氧核苷的高效化学酶法合成。
Efficient chemo-enzymatic syntheses of pharmaceutically useful unnatural 2'-deoxynucleosides.
作者信息
Komatsu Hironori, Araki Tadashi
机构信息
Catalysis Science Laboratory, Mitsui Chemicals, Inc., Chiba, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):1127-30. doi: 10.1081/ncn-200060154.
PMID:16248106
Abstract
Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2'-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-alpha-D-ribose 1-phosphate (dRP) to CdA; 2) a two-step route via 9-(2-deoxy-beta-D-ribos-1-yl)-2, 6-dichloropurine (Cl2Pu-dR, 5).
摘要
我们的化学酶法已成功应用于2-氯-2'-脱氧腺苷（CdA，克拉屈滨）的合成，有两种方式：1）将化学合成的2-脱氧-α-D-核糖1-磷酸（dRP）直接转化为CdA；2）通过9-(2-脱氧-β-D-核糖-1-基)-2,6-二氯嘌呤（Cl2Pu-dR，5）的两步路线。
Zotero 插件