Gao Jing, Ruan Xinyong, Pan Xinliang, Xu Fenglei, Lei Dapeng, Liu Dayu
Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Aug;19(15):680-2.
To study the effect of sodium phenylbutyrate when it combined with agents used in induction chemotherapy on laryngeal carcinoma cells Hep-2 in vitro.
MTT were used to examine the growth inhibition of Hep-2 cells treated by the combination of PB with 5-FU or CDDP in vitro.
When 5-FU or CDDP combined with PB respectively, there was significantly difference between every two dose groups of the two agents or every dose group and control group ( P < 0.05). When the dosage of 5-FU or CDDP was definition,there was significantly difference between every two dose groups of PB ( P < 0.05).
PB could enhance the cytotoxic effects of agents used in induction chemotherapy on laryngeal carcinoma cells Hep-2 in vitro, which showed the possibility in reinforcement the treatment effect and reduction the occurrence of the complication and toxic reaction of induction chemotherapy on laryngeal carcinoma.
研究苯丁酸钠与诱导化疗药物联合应用对喉癌细胞Hep-2的体外作用。
采用MTT法检测苯丁酸钠（PB）分别与5-氟尿嘧啶（5-FU）或顺铂（CDDP）联合应用对体外培养的Hep-2细胞的生长抑制作用。
5-FU或CDDP分别与PB联合应用时，两药各剂量组间及各剂量组与对照组比较差异均有统计学意义（P<0.05）。当5-FU或CDDP剂量一定时，PB各剂量组间比较差异有统计学意义（P<0.05）。
PB可增强诱导化疗药物对喉癌细胞Hep-2的体外细胞毒作用，提示其在增强喉癌诱导化疗疗效、降低并发症及毒副反应发生方面具有一定可能性。
