Different gamma/delta T clones sustain GVM and GVH effects in multiple myeloma patients after non-myeloablative transplantation.
作者信息
Galimberti Sara, Benedetti Edoardo, Morabito Fortunato, Petrini Iacopo, Battolla Barbara, Papineschi Federico, Fazzi Rita, Ciabatti Elena, Martino Massimo, Cuzzola Mariella, Console Giuseppe, Iacopino Pasquale, Petrini Mario
机构信息
Department of Oncology, Transplant and Advances in Medicine, Section of Hematology, University of Pisa, Ospedale S. Chiara, Via Roma, 56, 56100 PISA, Italy.
出版信息
Leuk Res. 2006 May;30(5):529-35. doi: 10.1016/j.leukres.2005.09.004. Epub 2005 Oct 24.
TCR gamma/delta profiles were analyzed in 13 multiple myeloma patients after allogeneic non-myeloablative transplantation. Results show that both aGVHD and minimal residual disease (MRD) eradication did significantly affect TCR gamma/delta profile. During follow-up, six patients developed an aGVHD episode; in five of them, this event fitted with a modification of the TCR profile. Eleven patients achieved PCR-negativity during follow-up. In the 90% of them, the appearance of a new predominant TCR peak was concomitant to the disappearance of the IgH clone. These results suggest that different T gamma/delta populations would sustain GVM and GVH effects after non-myeloablative allogeneic transplant.
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