γδ T 细胞在造血干细胞移植中的作用。
The Roles of γδ T Cells in Hematopoietic Stem Cell Transplantation.
机构信息
Institute of Hematology, School of Medicine, 47885Jinan University, Guangzhou, China.
Key Laboratory for Regenerative Medicine of Ministry of Education, 47885Jinan University, Guangzhou, China.
出版信息
Cell Transplant. 2020 Jan-Dec;29:963689720966980. doi: 10.1177/0963689720966980.
The αβ T-cell-depleted hematopoietic stem cell transplantation (HSCT) leads to lower relapse and better outcome, and may correlate strongly with expansion of donor-derived γδ T cells. γδ T cells play an important role in immune reconstitution and can exert a graft-versus-leukemia effect after HSCT. This review showed the recent literature on immune functions of γδ T cells after HSCT. The discrepancies between studies of γδ T cells in graft-versus-host disease may cause by its heterogeneous and various distinct subsets. And reconstitution of γδ T cells may play a potential immunoregulatory role in the infections after HSCT.
αβ T 细胞耗竭的造血干细胞移植（HSCT）可降低复发率并改善预后，这可能与供体来源的 γδ T 细胞的扩增密切相关。γδ T 细胞在免疫重建中发挥重要作用，并可在 HSCT 后发挥移植物抗白血病作用。本综述介绍了 HSCT 后 γδ T 细胞免疫功能的最新文献。移植物抗宿主病中 γδ T 细胞的研究结果存在差异，可能是由于其异质性和不同的亚群。γδ T 细胞的重建可能在 HSCT 后感染中发挥潜在的免疫调节作用。
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