Chouinard Marie-Josée, Nguyen Dang-Khoa, Clément Jean-François, Bruneau Marie-Andrée
Department of Psychiatry and Neurology, CHUM Hôpital Notre Dame, 1560 rue Sherbrooke Est, Montréal (Québec), Canada H2L 4M1.
Epilepsy Behav. 2006 Feb;8(1):303-7. doi: 10.1016/j.yebeh.2005.04.016. Epub 2005 Oct 24.
Levetiracetam (Keppra) is a novel antiepileptic drug approved as adjunctive treatment for adults with partial onset seizures. Although the drug is generally well tolerated, behavioral side effects have been reported in variable frequency. Most behavioral problems are mild in nature (agitation, hostility, anxiety, emotional lability, apathy, depression) and quickly resolve with discontinuation of medication. However, serious psychiatric adverse events may also occur with rare cases of psychosis and suicidal behavior. We report here the case of a 43-year-old woman who developed symptoms compatible with catatonia after being exposed to levetiracetam for the treatment of epilepsy. To our knowledge, it is the first reported case of catatonia induced by levetiracetam. We review the difficulties that may be encountered in the differential diagnosis of medical catatonia.
左乙拉西坦（开浦兰）是一种新型抗癫痫药物，被批准作为成人部分性发作的辅助治疗药物。尽管该药物通常耐受性良好，但已报告有不同频率的行为副作用。大多数行为问题性质较轻（激动、敌意、焦虑、情绪不稳定、冷漠、抑郁），停药后可迅速缓解。然而，也可能发生严重的精神不良反应，罕见的有精神病和自杀行为病例。我们在此报告一例43岁女性，在接受左乙拉西坦治疗癫痫后出现与紧张症相符的症状。据我们所知，这是首例左乙拉西坦诱发紧张症的报告病例。我们回顾了在医学性紧张症鉴别诊断中可能遇到的困难。
