环孢素A治疗银屑病的临床经验。一项回顾性研究的结果。

Clinical experience with the use of cyclosporin A in psoriasis. Results of a retrospective study.

作者信息

Ojeda R, Sánchez Regaña M, Massana J, Oliete R, Umbert P

机构信息

Psoriasis Unit, Department of Dermatology, Hospital Sagrat Cor, Barcelona, Spain.

出版信息

J Dermatolog Treat. 2005;16(4):238-41. doi: 10.1080/09546630510011829.

DOI:10.1080/09546630510011829

PMID:16249146

Abstract

The efficacy of cyclosporin A (Sandimmun Neoral) in severe psoriasis was analysed in 70 patients included in a retrospective descriptive study conducted at our Dermatology Department from January 1994 until December 2000. After 8 weeks of treatment, with an initial dose of 2.5-3 mg/kg/day, the reduction in the Psoriasis Area and Severity Index (PASI) score was>75% in 61% of patients. Most of the side effects observed turned out to be susceptible to being reversed over time or by dose reduction. The results of this study show that continuous and low-dose cyclosporin therapy is a safe and efficacious treatment for severe chronic psoriasis.

摘要

1994年1月至2000年12月在我们皮肤科进行的一项回顾性描述性研究纳入了70例患者，分析了环孢素A（新山地明）治疗重度银屑病的疗效。初始剂量为2.5 - 3mg/kg/天，治疗8周后，61%的患者银屑病面积和严重程度指数（PASI）评分降低>75%。观察到的大多数副作用随着时间推移或通过降低剂量是可以逆转的。本研究结果表明，持续低剂量环孢素治疗重度慢性银屑病是一种安全有效的治疗方法。