Elia Yesmino T, Daneman Denis, Rovet Joanne, Abdolell Mohamed, Lam Wai-Ching, Till Christine, Erraguntla Vasudha, Rubab Shehla, Lodha Nidhi, Westall Carol A
Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children and University of Toronto, Canada.
Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4107-13. doi: 10.1167/iovs.05-0178.
To examine the association between metabolic control (HbA(1c)) and the chromatic mechanisms of children with type 1 diabetes (T1D), by using the color visual evoked potential (VEP).
Fifty children with T1D (age range, 6-12.9 years) and 33 age-matched control subjects were tested. VEPs were recorded by placing five electrodes on the scalp according to the International 10/20 System of Electrode Placement. Active electrodes O1, O2, and Oz were placed over the visual cortex. Short-wavelength (S), and long- and medium-wavelength (LM) color stimuli consisted of vertical, photometric isoluminant (1 cyc/deg) gratings presented in a pattern onset (100 ms)-offset (400 ms) mode. Achromatic vertical gratings were presented at 3 cyc/deg. Primary outcome measure was VEP latency. The relationship between S, LM, and achromatic VEP latency, and HbA(1c) was determined by ANCOVA regression.
S-, LM-, achromatic VEP latencies were not associated significantly with HbA(1c). Pubertal status, however, was associated significantly (P = 0.0114) and selectively with S-VEP latency. Pubertal children with T1D had delayed (mean delay, 9.5 ms) S-VEP latencies when compared with the prepubertal children with T1D. However, there was no statistically significant difference (P = 0.1573) in the effect of pubertal status on S-VEP latency between the T1D and control groups.
Pubertal status rather than HbA(1c) appears to affect selectively the S-VEP latency of preteen children with T1D. Further study is warranted to determine whether the delay in S-VEP latency in pubertal children with T1D changes over time and whether this change could be a predictive marker for future development of background diabetic retinopathy.
通过使用颜色视觉诱发电位（VEP），研究1型糖尿病（T1D）患儿的代谢控制（糖化血红蛋白[HbA₁c]）与色觉机制之间的关联。
对50名T1D患儿（年龄范围6 - 12.9岁）和33名年龄匹配的对照受试者进行测试。根据国际10/20电极放置系统，在头皮上放置五个电极记录VEP。活动电极O1、O2和Oz置于视觉皮层上方。短波长（S）以及长波长和中波长（LM）颜色刺激由垂直的、光度等亮度（1周/度）光栅组成，以模式起始（100毫秒） - 偏移（400毫秒）模式呈现。非彩色垂直光栅以3周/度呈现。主要观察指标为VEP潜伏期。通过协方差分析回归确定S、LM和非彩色VEP潜伏期与HbA₁c之间的关系。
S、LM和非彩色VEP潜伏期与HbA₁c无显著关联。然而，青春期状态与S - VEP潜伏期有显著关联（P = 0.0114）且具有选择性。与青春期前的T1D患儿相比，青春期T1D患儿的S - VEP潜伏期延迟（平均延迟9.5毫秒）。然而，青春期状态对T1D组和对照组S - VEP潜伏期的影响在统计学上无显著差异（P = 0.1573）。
青春期状态而非HbA₁c似乎选择性地影响青春期前T1D患儿的S - VEP潜伏期。有必要进一步研究青春期T1D患儿的S - VEP潜伏期延迟是否随时间变化，以及这种变化是否可能成为未来背景性糖尿病视网膜病变发展的预测指标。
