Wolter Daniel J, Hanson Nancy D, Lister Philip D
Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178, USA.
Antimicrob Agents Chemother. 2005 Nov;49(11):4763-6. doi: 10.1128/AAC.49.11.4763-4766.2005.
Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.
过表达mexCD-oprJ的铜绿假单胞菌菌株对亚胺培南变得高度敏感。有人提出AmpC诱导的破坏会导致这种表型。然而,这项研究的数据表明,在ampC表达或AmpC活性没有变化的情况下,也会出现对亚胺培南的高度敏感性。此外,高度敏感性不是由外膜孔蛋白OprD的表达变化引起的。