结核分枝杆菌的mmpL7基因负责耻垢分枝杆菌中异烟肼的外排。
mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis.
作者信息
Pasca Maria R, Guglierame Paola, De Rossi Edda, Zara Francesca, Riccardi Giovanna
机构信息
Dipartimento di Genetica e Microbiologia, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy.
出版信息
Antimicrob Agents Chemother. 2005 Nov;49(11):4775-7. doi: 10.1128/AAC.49.11.4775-4777.2005.
Abstract
The Mycobacterium tuberculosis mmpL7 gene, encoding a hypothetical resistance nodulation division transporter, confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (carbonyl cyanide m-chlorophenylhydrazone). Energy-dependent efflux of isoniazid from M. smegmatis cells expressing the mmpL7 gene was observed.
摘要
结核分枝杆菌的mmpL7基因编码一种假定的抗药结节分化转运蛋白，当在耻垢分枝杆菌中过表达时，赋予对异烟肼的高抗性水平。在存在外排泵抑制剂利血平和CCCP（羰基氰化物间氯苯腙）的情况下，抗性水平降低。观察到异烟肼从表达mmpL7基因的耻垢分枝杆菌细胞中进行能量依赖性外排。
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