Chaung J H, Chen L
Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China.
J Pediatr Surg. 1992 May;27(5):662-4. doi: 10.1016/0022-3468(92)90474-l.
Gliomatosis peritonei (GP) is a rare occurrence associated exclusively with ovarian teratoma (OT), in which numerous metastatic nodules composed mainly of mature glial tissue are studded on the peritoneum, omentum, and bowel wall. Two female patients (aged 5 years and 14 years) are reported. Various preoperative examinations confirmed a large abdominal teratoma with normal alpha-fetoprotein and beta-HCG. The OT was excised and partial omentectomy and incidental appendectomy were performed to remove as many metastatic nodules as possible. Pathological examinations including immunostains for glial fibrillary acidic protein showed predominantly mature glial tissue in the OT and in the metastatic nodules. An addition, chemotherapy was given to one of them, but both were well without recurrent diseases 17 months and 12 months postoperatively, respectively. The outcome of these two cases, in contrast to advanced malignancy in widespread intraperitoneal metastases of any other kind, supports the concept of benign nature of GP and a conservative surgical approach to this rare disorder.
腹膜胶质细胞瘤（GP）是一种仅与卵巢畸胎瘤（OT）相关的罕见病症，其中大量主要由成熟神经胶质组织构成的转移结节散布于腹膜、大网膜和肠壁。本文报道了两名女性患者（年龄分别为5岁和14岁）。各种术前检查证实存在一个巨大的腹部畸胎瘤，甲胎蛋白和β-人绒毛膜促性腺激素水平正常。切除了OT，并进行了部分大网膜切除术和附带的阑尾切除术，以尽可能多地清除转移结节。包括胶质纤维酸性蛋白免疫染色在内的病理检查显示，OT和转移结节中主要为成熟神经胶质组织。此外，其中一名患者接受了化疗，但两人分别在术后17个月和12个月时均情况良好，无疾病复发。与任何其他类型广泛腹膜内转移的晚期恶性肿瘤相比，这两个病例的结果支持了GP为良性性质的概念以及对这种罕见病症采取保守手术方法的观点。
