Cacoub Patrice, Saadoun David, Limal Nicolas, Léger Jean Marc, Maisonobe Thierry
Department of Internal Medicine, Hôpital La Pitié-Salpêtrière, Paris, France.
AIDS. 2005 Oct;19 Suppl 3:S128-34. doi: 10.1097/01.aids.0000192081.33938.2f.
Chronic liver disease caused by hepatitis C virus (HCV) infection is commonly associated with extrahepatic manifestations, mainly mixed cryoglobulinaemia. Neurological complications in HCV-infected patients occur predominantly in the peripheral nervous system. Peripheral neuropathy in HCV infection is primarily associated with mixed cryoglobulinaemia. Central nervous system (CNS) involvement is more rarely reported. In this review, peripheral and CNS involvement associated with chronic HCV infection are described. The underlying mechanisms and treatment possibilities are discussed.
丙型肝炎病毒(HCV)感染所致的慢性肝病通常与肝外表现相关,主要是混合性冷球蛋白血症。HCV感染患者的神经并发症主要发生在周围神经系统。HCV感染中的周围神经病变主要与混合性冷球蛋白血症有关。中枢神经系统(CNS)受累的报道较少。在本综述中,描述了与慢性HCV感染相关的周围和中枢神经系统受累情况。并讨论了其潜在机制和治疗可能性。